Replacement therapy in primary immunodeficiency syndrome Starting dose: 0.4-0.8 g/kg; thereafter 0.2-0.8 g/kg every 2-4 wk to obtain IgG trough level of at least 4-6 g/L.
Replacement therapy in myeloma or chronic lymphocytic leukaemia w/ severe hypogammaglobulinaemia & recurrent infections; replacement therapy in childn w/ AIDS & recurrent infection 0.2-0.4 g/kg every 3-4 wk.
ITP 0.8-1 g/kg on day 1, may be repeated once w/in 3 days, or 0.4 g/kg/day for 2-5 days.
Guillain-Barre syndrome 0.4 g/kg/day for 3-7 days.
Kawasaki disease 1.6-2 g/kg in divided doses for 2-5 days or 2 g/kg as a single dose in combination w/ acetylsalicylic acid.
Allogeneic bone marrow transplantation 0.5 g/kg wkly starting 7 days before & up to 3 mth after transplantation in the treatment of infections & prophylaxis of graft versus host disease, & 0.5 g/kg mthly until Ab levels return to normal in cases of persistent lack of Ab production.
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